Cyrus C B, Bielamowicz S, Evans F J, Ludlow C L
Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1416, USA.
Otolaryngol Head Neck Surg. 2001 Jan;124(1):23-30. doi: 10.1067/mhn.2001.112572.
To determine laryngeal muscle activation abnormalities associated with speech symptoms in abductor spasmodic dysphonia (ABSD).
Bilateral laryngeal muscle recordings from the posterior cricoarytenoid, thyroarytenoid, and cricothyroid muscles were conducted in 12 ABSD patients. Patients' measures were compared during speech breaks and during speech without breaks and with 10 normal controls.
Significant group differences were found in the thyroarytenoid muscle; the patients had significantly greater activity on the right side both during speech breaks and nonbreaks in comparison with the controls. Cricothyroid muscle levels were also increased on the right in the patients.
An asymmetry in adductor muscle tone between the 2 sides in ABSD may account for difficulties with maintaining phonation and voice onset after voiceless consonants.
These abnormalities may indicate why PCA BOTOX injections have not been as effective in ABSD as thyroarytenoid injections have been in adductor spasmodic dysphonia.
确定外展性痉挛性发声障碍（ABSD）中与言语症状相关的喉肌激活异常。
对12例ABSD患者的环杓后肌、甲杓肌和环甲肌进行双侧喉肌记录。在言语停顿期间、无停顿言语期间对患者的测量结果进行比较，并与10名正常对照者进行比较。
甲杓肌存在显著的组间差异；与对照组相比，患者在言语停顿和无停顿期间右侧的活动明显更强。患者右侧的环甲肌水平也有所升高。
ABSD两侧内收肌肌张力不对称可能是导致维持发声以及发清辅音后起音困难的原因。
这些异常可能表明为什么环杓后肌肉毒杆菌毒素注射在ABSD中不如甲杓肌注射在内收性痉挛性发声障碍中有效。
