Sciscione A C, Manley J S, Pollock M, Maas B, Shlossman P A, Mulla W, Lankiewicz M, Colmorgen G H
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware 19718, USA.
Am J Obstet Gynecol. 2001 Feb;184(3):368-73. doi: 10.1067/mob.2001.111796.
We report our experience with a transvaginally applied intracervical fibrin sealant at <24 weeks' gestation.
This is an observational study of a referred patient population, with preterm premature rupture of the membranes at <24 weeks' gestation.
Twelve women consented to our protocol. The mean gestational age at preterm premature rupture of membranes was 19 weeks 4 days (range, 13-23 weeks); the mean gestational age at treatment was 20 weeks 5 days (range, 17-23 weeks). All women had a diminution in the amount of amniotic fluid leakage with an increase in amniotic fluid index. Among the 12 pregnancies (13 fetuses), there were 7 surviving neonates. Two women had apparent "resealing" of the membranes.
Fibrin sealants in midtrimester rupture of the membranes may lead to improved outcomes and now warrant formal evaluation.
我们报告了在妊娠<24周时经阴道应用宫颈内纤维蛋白密封剂的经验。
这是一项对转诊患者群体的观察性研究，这些患者在妊娠<24周时发生胎膜早破。
12名女性同意参与我们的方案。胎膜早破时的平均孕周为19周4天（范围为13 - 23周）；治疗时的平均孕周为20周5天（范围为17 - 23周）。所有女性羊水渗漏量均减少，羊水指数增加。在这12次妊娠（13例胎儿）中，有7例新生儿存活。2名女性的胎膜出现明显“重新封闭”。
孕中期胎膜破裂时使用纤维蛋白密封剂可能会改善结局，目前值得进行正式评估。
