Devlieger R, Millar L K, Bryant-Greenwood G, Lewi L, Deprest J A
Centre for Surgical Technologies and Department of Obstetrics and Gynecology, University Hospitals, Katholieke Universiteit Leuven, Leuven, Belgium.
Am J Obstet Gynecol. 2006 Dec;195(6):1512-20. doi: 10.1016/j.ajog.2006.01.074. Epub 2006 May 8.
In view of the important protective role of the fetal membranes, wound sealing, tissue regeneration, or wound healing could be life saving in cases of preterm premature rupture of the membranes. Although many investigators are studying the causes of preterm premature rupture of membranes, the emphasis has not been on the wound healing capacity of the fetal membranes. In this review, the relevant literature on the pathophysiologic condition that leads to preterm premature rupture of membranes will be summarized to emphasize a continuum of events between rupture and repair. We will present the current knowledge on fetal membrane wound healing and discuss the clinical implications of these findings. We will critically discuss recent experimental interventions in women to seal or heal the fetal membranes after preterm premature rupture of membranes.
鉴于胎膜具有重要的保护作用，在胎膜早破的情况下，伤口封闭、组织再生或伤口愈合可能挽救生命。尽管许多研究人员正在研究胎膜早破的原因，但重点并未放在胎膜的伤口愈合能力上。在本综述中，将总结导致胎膜早破的病理生理状况的相关文献，以强调破裂与修复之间的一系列连续事件。我们将介绍目前关于胎膜伤口愈合的知识，并讨论这些发现的临床意义。我们将批判性地讨论近期针对胎膜早破后女性进行的封闭或愈合胎膜的实验性干预措施。
