Drejewicz H, Toczynska B
Zaklad Immunologii, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211, Warszawa, Poland.
Med Wieku Rozwoj. 2000 Oct-Dec;4(4):431-9.
The aim of the study was the evaluation of multiresistant strains in infections of children treated at the National Research Institute of Mother and Child (NRIMC). During 1999, 23145 inoculations and 3873 antibiotic susceptibility tests were done. 2711 multiresistant strains were detected of which 59.2% were Gram-negative rods and 40.8% - Gram-positive cocci. The Gram-negative rods were tested for production of beta-lactamases (ESBL), resistance to aminoglicosides, imipenem and piperacillin/tazobactam. Gram-positive cocci were tested for methicilin and aminoglicosides resistance. Cross-resistance between macrolides, lincosamides and streptogramines was also investigated. Significant participation of multiresistant bacterial strains, mainly Gram-negative, in infections among patients treated in intensive care units of the Institute should be stressed.
本研究的目的是评估在国立妇幼研究所（NRIMC）接受治疗的儿童感染中的多重耐药菌株。1999年期间，进行了23145次接种和3873次抗生素敏感性试验。检测到2711株多重耐药菌株，其中59.2%为革兰氏阴性杆菌，40.8%为革兰氏阳性球菌。对革兰氏阴性杆菌进行了β-内酰胺酶（ESBL）产生情况、对氨基糖苷类、亚胺培南和哌拉西林/他唑巴坦耐药性的检测。对革兰氏阳性球菌进行了耐甲氧西林和耐氨基糖苷类检测。还研究了大环内酯类、林可酰胺类和链阳菌素之间的交叉耐药性。应强调多重耐药菌株，主要是革兰氏阴性菌，在该研究所重症监护病房接受治疗的患者感染中所占的显著比例。
