Butler W R, Krey L C, Espinosa-Campos J, Knobil E
Endocrinology. 1975 May;96(5):1094-8. doi: 10.1210/endo-96-5-1094.
The effects of complete and anterior disconnection of the medial basal hypothalamus (MBH( on TSH secretion in the rhesus monkey were assessed by measuring serum thyroxine concentrations. Following complete MBH disconnection, serum thyroxine concentrations declined to 50% of preoperative control levels within 7 days. In 6 of 10 animals, thyroxine levels remained depressed throughout the postoperative observation period of 60 to 150 days. In the remainder, serum thyroxine concentrations returned to control levels after 3 weeks. Anterior disconnection of the MBH had variable effects on thyroid function. In 4 of 7 animals, serum thyroxine concentrations declined for 5 days following the operation but returned to preoperative levels within the next 3 weeks. In 2 others, serum thyroxine levels did not change while in the remaining animal thyroxine concentrations increased transiently to twice preoperative levels before returning to normal values. Thus, in the monkey, as in the rat, anterior MBH disconnection has little consistent effect on thyroid function, while complete isolation of the MBH causes a moderate decline which is most readily attributable to a decrease in thyrotropin secretion. The variations in the effects of anterior and complete MBH disconnection on thyroid function could not be confidently correlated with variations in the placement of the cuts.
通过测量血清甲状腺素浓度，评估恒河猴内侧基底下丘脑（MBH）完全切断和前部切断对促甲状腺激素（TSH）分泌的影响。MBH完全切断后，血清甲状腺素浓度在7天内降至术前对照水平的50%。在10只动物中的6只，甲状腺素水平在术后60至150天的观察期内一直处于低水平。其余动物中，血清甲状腺素浓度在3周后恢复到对照水平。MBH前部切断对甲状腺功能有不同影响。7只动物中的4只，术后血清甲状腺素浓度下降5天，但在接下来的3周内恢复到术前水平。另外2只动物血清甲状腺素水平未改变，而其余1只动物甲状腺素浓度在恢复到正常值之前短暂升高至术前水平的两倍。因此，在猴子中，与在大鼠中一样，MBH前部切断对甲状腺功能几乎没有一致的影响，而MBH完全分离会导致中度下降，这最容易归因于促甲状腺激素分泌减少。MBH前部切断和完全切断对甲状腺功能影响的差异与切口位置的差异没有可靠的相关性。
