Bulter W R, Krey L C, Lu K H, Peckham W D, Knobil E
Endocrinology. 1975 May;96(5):1099-105. doi: 10.1210/endo-96-5-1099.
The effects of anterior and complete hypothalamic deafferentation on prolactin secretion in the rhesus monkey have been assessed. Complete disconnection ofthe medial basal hypothalamus (MBH) had no apparent effect on serum prolactin concentrations, in either intact or ovariectomized monkeys, nor did it diminish the stimulation of prolactin secretion induced by sodium pentobarbital anesthesia. Anterior disconnection of the MBH in intact females was also without effect on prolactin secretion. When the MBH was inadvertently damaged during the complete disconnection procedure, serum prolactin levels increased approximately 5-fold in otherwise intact animals while remaining unchanged in ovariectomized monkeys, thereby suggesting that ovarian hormones may modulate the secretion of prolactin in response to a reduction of hypothalamic inhibitory influences. In contrast, basal serum prolactin concentrations were not notably influenced by ovariectomy or estrogen administration nor were the patterns of prolactin secretion related to the phases of the menstrual cycle. The results of these studies suggest that the consequences of complete MBH disconnection on prolactin secretion are essentially the same in the rhesus monkey and in the rat, although major differences exist between these species with regard to the influence of estrogen on the production of this hormone.
已经评估了下丘脑前部和完全去传入对恒河猴催乳素分泌的影响。在内侧基底下丘脑（MBH）完全切断的情况下，无论是完整的还是去卵巢的猴子，血清催乳素浓度均无明显变化，戊巴比妥钠麻醉诱导的催乳素分泌刺激也未减弱。完整雌性动物中MBH的前部切断对催乳素分泌也没有影响。在完全切断过程中MBH意外受损时，在其他方面完整的动物中血清催乳素水平增加了约5倍，而去卵巢的猴子中血清催乳素水平保持不变，从而表明卵巢激素可能会响应下丘脑抑制作用的降低来调节催乳素的分泌。相比之下，基础血清催乳素浓度不受去卵巢或雌激素给药的显著影响，催乳素分泌模式也与月经周期阶段无关。这些研究结果表明，MBH完全切断对催乳素分泌的影响在恒河猴和大鼠中基本相同，尽管在雌激素对这种激素产生的影响方面，这两个物种之间存在主要差异。
