Okada M, Shibuya M, Yamamoto E, Murakami Y
Faculty of Health and Living Sciences, Naruto University of Education, Takashima 772-8502, Naruto, Japan. mailto:
Diabetes Obes Metab. 1999 Jul;1(4):221-5. doi: 10.1046/j.1463-1326.1999.00028.x.
In the diabetic state, energy must be supplied mainly by amino acids and fat; therefore the metabolic processes are very similar to those of animals fed a high-protein diet. Vitamin B6-dependent enzymes, which are highly involved in amino acid metabolism, are important in diabetics. We investigated vitamin B6 content, and aspartate aminotransferase and glycogen phosphorylase activities, in several tissues of streptozotocin-induced diabetic and control rats.
The rats were fed a vitamin B6-free diet and administered an equivalent amount of pyridoxine based on body weight.
Vitamin B6 content in all tissues examined, except for the liver, was lower in the diabetics than in controls. Aspartate aminotransferase activity was higher in the liver of diabetics than in the controls, but not in the other tissues. Glycogen phosphorylase activity in the gastrocnemius muscle of diabetics decreased to two-thirds of the control level.
These data might indicate that diabetic animals should have a higher intake of vitamin B6 because a diabetic state can lead to a vitamin B6-deficiency.
在糖尿病状态下，能量必须主要由氨基酸和脂肪提供；因此，代谢过程与喂食高蛋白饮食的动物非常相似。高度参与氨基酸代谢的维生素B6依赖性酶在糖尿病患者中很重要。我们研究了链脲佐菌素诱导的糖尿病大鼠和对照大鼠的几种组织中的维生素B6含量、天冬氨酸氨基转移酶和糖原磷酸化酶活性。
给大鼠喂食不含维生素B6的饮食，并根据体重给予等量的吡哆醇。
除肝脏外，所有检测组织中的糖尿病大鼠维生素B6含量均低于对照组。糖尿病大鼠肝脏中的天冬氨酸氨基转移酶活性高于对照组，但其他组织中则不然。糖尿病大鼠腓肠肌中的糖原磷酸化酶活性降至对照水平的三分之二。
这些数据可能表明糖尿病动物应该摄入更多的维生素B6，因为糖尿病状态会导致维生素B6缺乏。
