Harman S M, Louvet J P, Ross G T
Endocrinology. 1975 May;96(5):1119-22. doi: 10.1210/endo-96-5-1119.
Inhibition by antiestradiol serum of ovarian weight gain and follicular growth in hypophysectomized immature rats given FSH and hCG suggested that gonadotrophin induced endogenous estrogen secretion plays a role in the ovarian augmentation reaction. We have studied the effects of a chemical estrogen antagonist, cis-clomiphene, on ovarian weight response to gonadotrophins in hypophysectomized immature female rats. We found that this antiestrogen inhibits the ovarian response to FSH and hCG. To our knowledge, this is the first demonstration of a direct effect of a chemical antiestrogen on the ovary, a result consistent with a role for intraovarian estrogen in follicular growth.
抗雌二醇血清对给予促卵泡激素（FSH）和人绒毛膜促性腺激素（hCG）的垂体切除未成熟大鼠卵巢重量增加和卵泡生长的抑制作用表明，促性腺激素诱导的内源性雌激素分泌在卵巢增大反应中起作用。我们研究了化学雌激素拮抗剂顺式氯米芬对垂体切除未成熟雌性大鼠卵巢对促性腺激素重量反应的影响。我们发现这种抗雌激素抑制卵巢对FSH和hCG的反应。据我们所知，这是化学抗雌激素对卵巢直接作用的首次证明，这一结果与卵巢内雌激素在卵泡生长中的作用一致。
