Harman S M, Louvet J P, Ross G T
Endocrinology. 1975 May;96(5):1145-52. doi: 10.1210/endo-96-5-1145.
We have investigated folluclar atresia by giving hypophysectomized immature female rats (HIFR) diethylstibestrol or gonadotrophins with and without the chemical antiestrogen CI-628, making total counts of normal and atretic follicles greater than 125 muM in diameter, and using a simple model to analyze data. Our results show an antiatretic effect of estrogen, independent of its well-documented mitogenic effect on preantral follicles. We have also shown that CI-628 acts as an anti-estrogen to block follicular proliferation, while acting as an estrogen to inhibit atresia. In addition, we have observed an increase in atresia caused by gonadotrophins, in opposition to their estrogen-mediated positive effect on follicular growth.
我们通过给垂体切除的未成熟雌性大鼠（HIFR）注射己烯雌酚或促性腺激素，并同时给予或不给予化学抗雌激素CI-628，来研究卵泡闭锁。我们对直径大于125微米的正常卵泡和闭锁卵泡进行了总数统计，并使用一个简单模型来分析数据。我们的结果表明，雌激素具有抗闭锁作用，这与其对窦前卵泡的促有丝分裂作用无关。我们还表明，CI-628作为一种抗雌激素可阻断卵泡增殖，同时作为一种雌激素可抑制闭锁。此外，我们观察到促性腺激素会导致闭锁增加，这与其对卵泡生长的雌激素介导的正向作用相反。
