Pugh K R, Mencl W E, Shaywitz B A, Shaywitz S E, Fulbright R K, Constable R T, Skudlarski P, Marchione K E, Jenner A R, Fletcher J M, Liberman A M, Shankweiler D P, Katz L, Lacadie C, Gore J C
Department of Pediatrics, Yale University School of Medicine, P.O. Box 3333, New Haven, CT 06510-8064, USA.
Psychol Sci. 2000 Jan;11(1):51-6. doi: 10.1111/1467-9280.00214.
Converging evidence from neuroimaging studies of developmental dyslexia reveals dysfunction at posterior brain regions centered in and around the angular gyrus in the left hemisphere. We examined functional connectivity (covariance) between the angular gyrus and related occipital and temporal lobe sites, across a series of print tasks that systematically varied demands on phonological assembly. Results indicate that for dyslexic readers a disruption in functional connectivity in the language-dominant left hemisphere is confined to those tasks that make explicit demands on assembly. In contrast, on print tasks that do not require phonological assembly, functional connectivity is strong for both dyslexic and nonimpaired readers. The findings support the view that neurobiological anomalies in developmental dyslexia are largely confined to the phonological-processing domain. In addition, the findings suggest that right-hemisphere posterior regions serve a compensatory role in mediating phonological performance in dyslexic readers.
来自发育性阅读障碍神经影像学研究的越来越多的证据表明，大脑后部区域存在功能障碍，该区域以左半球角回及其周围为中心。我们在一系列对语音组装要求系统变化的印刷任务中，检查了角回与相关枕叶和颞叶部位之间的功能连接（协方差）。结果表明，对于诵读困难的读者来说，语言优势半球左半球的功能连接中断仅限于那些对组装有明确要求的任务。相比之下，在不需要语音组装的印刷任务中，诵读困难的读者和未受影响的读者的功能连接都很强。这些发现支持了这样一种观点，即发育性阅读障碍中的神经生物学异常主要局限于语音处理领域。此外，这些发现表明，右半球后部区域在介导诵读困难读者的语音表现方面起到了补偿作用。
