Roy R, Jain M, Maheshwari S, Goyal R K
Department of Medicine, JLN Medical College and Hospital, Ajmer, Rajasthan.
J Assoc Physicians India. 2000 Feb;48(2):207-9.
The present study was done to observe the insulin secretory response in healthy adult offspring of normotensive and hypertensive parents as the etiology of essential hypertension is largely treated as unknown.
The insulin secretary response was observed in 20 healthy adult offspring of normotensive parents (Group I) and 25 healthy adult offspring of hypertensive parents (Group II). The mean serum insulin levels were assessed at fasting, 30, 60, 90 and 120 minutes after 75 grams of oral glucose load in both groups.
The mean serum insulin levels in fasting state was higher in group II (32.40 +/- 18.59) than group I (17.90 +/- 11.98) (p < 0.01). After 30 minutes mean serum insulin levels were higher in group II than group I (88.00 +/- 56.04, 40.5 +/- 15.15 respectively, p < 0.001). There was no statistically significant difference after 60, 90 and 120 minutes of oral glucose load (p > 0.05).
Our observations suggest that the insulin secretory response in fasting and 30 minutes after oral glucose load was earliest metabolic abnormality in subjects at high risk for developing hypertension i.e. offspring of hypertensive parents.
由于原发性高血压的病因在很大程度上仍不明，本研究旨在观察血压正常和高血压患者的健康成年子代的胰岛素分泌反应。
观察了20名血压正常者的健康成年子代（I组）和25名高血压患者的健康成年子代（II组）的胰岛素分泌反应。两组均于口服75克葡萄糖后空腹、30、60、90和120分钟时评估血清胰岛素平均水平。
II组空腹状态下血清胰岛素平均水平（32.40±18.59）高于I组（17.90±11.98）（p<0.01）。30分钟后，II组血清胰岛素平均水平高于I组（分别为88.00±56.04和40.5±15.15，p<0.001）。口服葡萄糖60、90和120分钟后，两组无统计学显著差异（p>0.05）。
我们的观察结果表明，空腹及口服葡萄糖后30分钟时的胰岛素分泌反应是高血压高危人群（即高血压患者的子代）最早出现的代谢异常。
