Gelsang Norpu, Cen Wei-jun, Dronma Tsering, Pingtso Tashi, Chen Yong, Zhou Wen-jun, Liu Guo-zhang
Department of Cardiology, Tibet Autonomous Region People's Hospital, Institute of cardiovascular disease and high altitude sickness, Lhasa 850000, China.
Zhonghua Yi Xue Za Zhi. 2003 Aug 10;83(15):1306-8.
To investigate the plasma insulin levels and insulin sensitivity in the offspring of parents with family hypertensive history in Tibetan population.
Tibetan hypertensive pedigrees and normotensive pedigrees based on a door-to-door cross section study performed from 1997 to 1998 in stable communities in the ruban district of Lhasa city were set up, 47 offsprings from hypertensive pedigrees (group I) and 21 offsprings from normotensive pedigrees (group II) were enrolled into this study. Plasma insulin levels using by radioimmunoassay and insulin sensitivity with the formulae insulin sensitivity = 1/(fasting plasma glucose x fasting plasma insulin) were compared between two groups.
There were no statistically significant differences in fasting blood glucose levels between group I and group II. But fasting plasma insulin level was 10.20 +/- 6.95 m IU/L in group I and 6.56 +/- 2.81 m IU/L in group II, respectively, and there were statistically significant differences between these two groups. The insulin sensitivity index in group I was significantly lower than that in group II (0.036 +/- 0.024 and 0.046 +/- 0.022, respectively).
Offspring of Tibetan hypertensive pedigrees were observed to be hyperinsulinemia and reduced insulin sensitivity. These metabolic abnormalities may be associated with hypertension and dyslipidemia in adulthood.
研究藏族人群中有家族高血压病史的父母的子代的血浆胰岛素水平和胰岛素敏感性。
基于1997年至1998年在拉萨市鲁般区稳定社区进行的逐户横断面研究，建立藏族高血压家系和正常血压家系，本研究纳入了47名高血压家系的子代（I组）和21名正常血压家系的子代（II组）。采用放射免疫法检测两组的血浆胰岛素水平，并通过胰岛素敏感性公式（胰岛素敏感性=1/（空腹血糖×空腹血浆胰岛素））比较两组的胰岛素敏感性。
I组和II组的空腹血糖水平无统计学显著差异。但I组的空腹血浆胰岛素水平为10.20±6.95 mIU/L，II组为6.56±2.81 mIU/L，两组之间存在统计学显著差异。I组的胰岛素敏感性指数显著低于II组（分别为0.036±0.024和0.046±0.022）。
观察到藏族高血压家系的子代存在高胰岛素血症和胰岛素敏感性降低。这些代谢异常可能与成年期的高血压和血脂异常有关。
