Hübler J, Sükösd F, Czipri M
Department of Urology, University Medical School, Pécs, Hungary.
Int Urol Nephrol. 2000;32(2):281-4. doi: 10.1023/a:1007142910479.
PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels.
The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an increase in PSA levels.
Tibia metastasis showed lower tissue activity of PSA than did the primary tumor in the prostate. The authors think this explains the zero PSA level when the metastasis developed.
The authors think based on their case that PSA free progression prostate cacncers may cases where the metastases do not produce PSA.
前列腺特异性抗原（PSA）被视为前列腺癌随访的最佳方法。根治性膀胱前列腺切除术后，前列腺癌很少在PSA水平为零或接近零的情况下复发。
作者自1989年以来一直使用PSA，仅发现1例胫骨转移时PSA水平未升高的病例。
胫骨转移灶的PSA组织活性低于前列腺原发肿瘤。作者认为这解释了转移发生时PSA水平为零的原因。
基于他们的病例，作者认为无PSA进展的前列腺癌可能是转移灶不产生PSA的情况。
