Takayama T K, Krieger J N, True L D, Lange P H
Department of Urology, University of Washington School of Medicine, Seattle.
J Urol. 1992 Nov;148(5):1541-2. doi: 10.1016/s0022-5347(17)36963-x.
Serum prostate specific antigen (PSA) is a sensitive tumor marker following definitive therapy for adenocarcinoma of the prostate. Detectable levels of PSA after radical prostatectomy indicate residual and/or recurrent cancer. Therefore, we were surprised to document recurrent cancer following radical retropubic prostatectomy in a man who had undetectable serum PSA levels. This observation suggests that careful clinical monitoring remains essential after definitive therapy, since rare patients may have recurrent and/or residual carcinoma despite undetectable levels of PSA.
血清前列腺特异性抗原（PSA）是前列腺腺癌根治性治疗后的一种敏感肿瘤标志物。根治性前列腺切除术后可检测到的PSA水平表明存在残留和/或复发性癌症。因此，我们很惊讶地记录到一名血清PSA水平检测不到的男性在耻骨后根治性前列腺切除术后出现了复发性癌症。这一观察结果表明，在根治性治疗后仔细的临床监测仍然至关重要，因为尽管PSA水平检测不到，但仍有罕见患者可能发生复发和/或残留癌。
