Suh Y G, Kim Y H, Park M H, Choi Y H, Lee H K, Moon J Y, Min K H, Shin D Y, Jung J K, Park O H, Jeon R O, Park H S, Kang S A
College of Pharmacy, Seoul National University, South Korea.
Bioorg Med Chem Lett. 2001 Feb 26;11(4):559-62. doi: 10.1016/s0960-894x(01)00004-x.
The structure-activity relationship and molecular modelings of a novel pimarane COX-2 inhibitor are reported. Particularly, a series of linker extended analogues designed on the basis of these studies exhibited significantly enhanced COX-2 inhibitory activities and selectivities.
