氨基糖苷类抗生素、新霉素及其衍生物作为HIV-1激活剂来源的RNA-蛋白质相互作用的有效抑制剂。
Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators.
作者信息
Hamasaki K, Ueno A
机构信息
Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohamna, Japan.
出版信息
Bioorg Med Chem Lett. 2001 Feb 26;11(4):591-4. doi: 10.1016/s0960-894x(01)00005-1.
Abstract
Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.
摘要
已经制备了含有精氨酸（RN）、芘（PCN）以及同时含有芘和精氨酸（PRN）的新霉素衍生物，并检测了它们与源自HIV-1激活区域、TAR和RRE RNA的RNA片段的结合情况。其中，PRN分别以与Tat和Rev肽相当的结合亲和力与TAR RNA或RRE RNA结合。
Zotero 插件