嗜寡营养菌作为监测无菌药品生产单元的工具。
Oligophilic bacteria as tools to monitor aseptic pharmaceutical production units.
作者信息
Nagarkar P P, Ravetkar S D, Watve M G
机构信息
Research Laboratory, Research Foundation, Serum Institute of India, Hadapsar, Pune, India.
出版信息
Appl Environ Microbiol. 2001 Mar;67(3):1371-4. doi: 10.1128/AEM.67.3.1371-1374.2001.
Abstract
The bacterial loads of air, surfaces, and personnel in clean rooms are routinely monitored using a set of standard media. Bacteria that can grow on these media are a tiny fraction of the total numbers in any environment. A substantial proportion of bacteria long thought to be unculturable were recently shown to be oligophilic. Oligophile counts in clean rooms in our studies exceeded the standard plate counts by up to 2 orders of magnitude. They responded to disinfection routines in ways similar to the responses of conventional bacteria. We suggest that oligophiles are better tools than conventional bacteria for environmental monitoring in aseptic pharmaceutical production units.
摘要
使用一组标准培养基对洁净室中的空气、表面和人员的细菌载量进行常规监测。能在这些培养基上生长的细菌只是任何环境中细菌总数的极小一部分。长期以来被认为不可培养的很大一部分细菌最近被证明是嗜寡菌。在我们的研究中，洁净室中的嗜寡菌数量比标准平板计数高出多达两个数量级。它们对消毒程序的反应方式与传统细菌相似。我们认为，在无菌制药生产单位的环境监测中，嗜寡菌比传统细菌是更好的工具。
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