Turner S T, Schwartz G L, Chapman A B, Boerwinkle E
Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
Hypertension. 2001 Feb;37(2 Pt 2):739-43. doi: 10.1161/01.hyp.37.2.739.
The T allele of the C825T polymorphism of the gene encoding the beta(3)-subunit of G proteins has been associated with increased sodium-hydrogen exchange and low renin in patients with essential hypertension. To assess its association with blood pressure response to diuretic therapy, we measured the C825T polymorphism in 197 blacks (134 men, 63 women) and 190 non-Hispanic whites (76 men, 114 women) with essential hypertension (mean+/-SD age 48+/-7 years), who underwent monotherapy with hydrochlorothiazide for 4 weeks. Mean declines in systolic and diastolic blood pressures were 6+/-2 (P:<0.001) and 5+/-1 (P:<0.001) mm Hg greater, respectively, in TT than in CC homozygotes. Responses in heterozygotes were intermediate between the homozygous groups. Other univariate predictors of greater blood pressure responses included black race, female gender, higher pretreatment blood pressure, older age, lower waist-to-hip ratio, and measures of lower renin-angiotensin-aldosterone system activity. After the effects of the other predictors were considered, the TT genotype remained a significant predictor of greater declines in systolic and diastolic blood pressures. Thus, the C825T polymorphism of the G protein beta(3)-subunit may help identify patients with essential hypertension who are more responsive to diuretic therapy.
G蛋白β(3)亚基编码基因C825T多态性的T等位基因，与原发性高血压患者钠氢交换增加及肾素水平降低有关。为评估其与利尿剂治疗血压反应的相关性，我们检测了197名黑人（134名男性，63名女性）和190名非西班牙裔白人（76名男性，114名女性）原发性高血压患者（平均±标准差年龄48±7岁）的C825T多态性，这些患者接受了4周的氢氯噻嗪单药治疗。TT纯合子的收缩压和舒张压平均下降幅度分别比CC纯合子大6±2（P<0.001）和5±1（P<0.001）mmHg。杂合子的反应介于纯合子组之间。血压反应更大的其他单变量预测因素包括黑人种族、女性性别、治疗前血压较高、年龄较大、腰臀比更低以及肾素-血管紧张素-醛固酮系统活性较低的指标。在考虑了其他预测因素的影响后，TT基因型仍然是收缩压和舒张压更大幅度下降的显著预测因素。因此，G蛋白β(3)亚基的C825T多态性可能有助于识别对利尿剂治疗反应更敏感的原发性高血压患者。
