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Are angiotensin II receptor blockers more efficacious than placebo in heart failure? Implications of ELITE-2. Evaluation of Losartan In The Elderly.

作者信息

Berry C, Norrie J, McMurray J J

出版信息

Am J Cardiol. 2001 Mar 1;87(5):606-7, A9. doi: 10.1016/s0002-9149(00)01439-9.

DOI:10.1016/s0002-9149(00)01439-9
PMID:11230847
Abstract

In the light of the recent randomized controlled trials in chronic heart failure, it is now commonly assumed that treatment with an angiotensin-receptor blocker (ARB) is equivalent to treatment with an angiotensin-converting enzyme (ACE) inhibitor. We performed an imputed placebo analysis using previous placebo-ACE inhibitor trials and the current ACE inhibitor-ARB comparison studies, which shows that ARBs may not even be superior to placebos, let alone an ACE inhibitor.

摘要

相似文献

1
Are angiotensin II receptor blockers more efficacious than placebo in heart failure? Implications of ELITE-2. Evaluation of Losartan In The Elderly.
Am J Cardiol. 2001 Mar 1;87(5):606-7, A9. doi: 10.1016/s0002-9149(00)01439-9.
2
Angiotensin II receptor antagonists and heart failure: angiotensin-converting-enzyme inhibitors remain the first-line option.血管紧张素II受体拮抗剂与心力衰竭:血管紧张素转换酶抑制剂仍是一线选择。
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3
[ELITE II. AT1-blockers not better, but more tolerable than ACE-inhibitors].[ELITE II研究:血管紧张素II受体拮抗剂不比血管紧张素转换酶抑制剂好,但耐受性更佳]
Internist (Berl). 2000 Jan;41(1):A37.
4
[A-II blocker or ACE inhibitor in heart failure? Captopril can't be beat].
MMW Fortschr Med. 1999 Nov 25;141(47):4-5.
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[Interview with the author of ELITE II. Cave: small studies of fatal illnesses].
MMW Fortschr Med. 1999 Nov 25;141(47):6.
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Evaluation of Losartan in the Elderly (ELITE) Trial: clinical implications.
Eur Heart J. 1997 Aug;18(8):1197-9. doi: 10.1093/oxfordjournals.eurheartj.a015425.
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Effects of losartan and captopril on QT dispersion in elderly patients with heart failure. ELITE study group.
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Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE).氯沙坦与卡托普利治疗65岁以上心力衰竭患者的随机试验(老年氯沙坦评估研究,ELITE)
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9
Comparison of losartan and captopril in ELITE II.
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[Review of randomized trials of angiotensin receptor blockers in the treatment of patients with congestive heart failure].[血管紧张素受体阻滞剂治疗充血性心力衰竭患者的随机试验综述]
Nihon Rinsho. 2001 Oct;59(10):2051-61.

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