Park H J, Lim S H, Kang H A, Byun D G, Houh D
Department of Dermatology, Holy Family Hospital, Catholic University of Korea.
Dermatol Surg. 2001 Jan;27(1):28-30.
Syringomas usually develop in women as multiple skin-colored papules primarily seen on the periocular regions and cheeks. They can cause cosmetic problems and lead to poor self-esteem. Though several treatment modalities have been established, such as excision, electro/cryosurgery, chemical peeling, and CO2 laser surgery, none of them are satisfactory due to their limitations and side effects, for example, pain, prolonged healing time, postoperative erythema/pigmentary changes, and scarring.
The objective of this study was to develop a new treatment method for syringoma and to minimize the side effects through selective destruction of the tumor.
Six patients with multiple periorbital syringomas were enrolled in this study. The surface epithelium of the syringomas was vaporized by CO2 laser, and black ink was introduced in order to allow penetration to the dermis using iontophoresis. Subsequently the artificial tattoos were removed by Q-switched alexandrite laser. The results were evaluated clinically by both physicians and patients at 1, 2, 4, and 8 weeks after treatment.
The majority of syringoma in the six patients disappeared by the first follow-up 1 week after treatment. There were no cases of prolonged erythema persisting beyond 2 weeks. Additional treatment was repeated in the same manner in order to remove the remaining syringomas in one patient. There were no recurrences during the 8-week follow-up period.
Our new treatment was safer, less painful, nonscarring, and there was a quicker recovery period and less of a burden to repeat treatment when necessary.
汗管瘤通常在女性中出现，表现为多个肤色丘疹，主要见于眼周区域和脸颊。它们会引起美容问题并导致自卑。尽管已经确立了几种治疗方式，如切除、电/冷冻手术、化学剥脱和二氧化碳激光手术，但由于其局限性和副作用，例如疼痛、愈合时间延长、术后红斑/色素变化以及瘢痕形成，这些方法都不尽人意。
本研究的目的是开发一种新的汗管瘤治疗方法，并通过选择性破坏肿瘤来尽量减少副作用。
六名患有多发性眶周汗管瘤的患者纳入本研究。用二氧化碳激光汽化汗管瘤的表面上皮，然后引入黑色墨水，以便通过离子导入使其渗透到真皮层。随后用调Q翠绿宝石激光去除人工纹身。在治疗后1、2、4和8周由医生和患者进行临床评估结果。
六名患者中的大多数汗管瘤在治疗后1周的首次随访时消失。没有出现持续超过2周的长期红斑病例。对一名患者以相同方式重复额外治疗以去除剩余的汗管瘤。在8周的随访期内没有复发。
我们的新治疗方法更安全、疼痛更少、无瘢痕形成，恢复期更快，并且在必要时重复治疗的负担更小。
