爱泼斯坦-巴尔病毒核蛋白EBNA-3C与人类转移抑制因子Nm23-H1相互作用：癌症转移的分子联系。
Epstein-Barr virus nuclear protein EBNA-3C interacts with the human metastatic suppressor Nm23-H1: a molecular link to cancer metastasis.
作者信息
Subramanian C, Cotter M A, Robertson E S
机构信息
Program in Cellular and Molecular Biology, Department of Microbiology and Immunology and the Comprehensive Cancer and Geriatrics Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.
出版信息
Nat Med. 2001 Mar;7(3):350-5. doi: 10.1038/85499.
Epstein-Barr virus (EBV) is an oncogenic virus associated with a number of human malignancies including Burkitt lymphoma, nasopharyngeal carcinoma, lymphoproliferative disease and, though still debated, breast carcinoma. A subset of latent EBV antigens is required for mediating immortalization of primary B-lymphocytes. Here we demonstrate that the carboxy-terminal region of the essential latent antigen, EBNA-3C, interacts specifically with the human metastatic suppressor protein Nm23-H1. Moreover, EBNA-3C reverses the ability of Nm23-H1 to suppress the migration of Burkitt lymphoma cells and breast carcinoma cells. We propose that EBNA-3C contributes to EBV-associated human cancers by targeting and altering the role of the metastasis suppressor Nm23-H1.
爱泼斯坦-巴尔病毒（EBV）是一种致癌病毒，与多种人类恶性肿瘤相关，包括伯基特淋巴瘤、鼻咽癌、淋巴增殖性疾病，以及（尽管仍存在争议）乳腺癌。介导原代B淋巴细胞永生化需要一部分潜伏性EBV抗原。在此，我们证明了必需潜伏抗原EBNA-3C的羧基末端区域与人转移抑制蛋白Nm23-H1特异性相互作用。此外，EBNA-3C可逆转Nm23-H1抑制伯基特淋巴瘤细胞和乳腺癌细胞迁移的能力。我们提出，EBNA-3C通过靶向并改变转移抑制因子Nm23-H1的作用，促进了与EBV相关的人类癌症。
Zotero 插件