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Innate immune induction of the adaptive immune response.

作者信息

Medzhitov R, Janeway C A

机构信息

Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520-8011, USA.

出版信息

Cold Spring Harb Symp Quant Biol. 1999;64:429-35. doi: 10.1101/sqb.1999.64.429.

DOI:10.1101/sqb.1999.64.429

PMID:11232318

Abstract

摘要

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Innate immune induction of the adaptive immune response.

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Nature. 2002 Nov 21;420(6913):329-33. doi: 10.1038/nature01180.

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Biochem Biophys Res Commun. 2003 Feb 7;301(2):495-501. doi: 10.1016/s0006-291x(02)03082-6.

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Cold Spring Harb Symp Quant Biol. 1999;64:473-83. doi: 10.1101/sqb.1999.64.473.

Wanted: a molecular basis for specificity in toll-like receptor signal transduction.

Mol Cell. 2002 Nov;10(5):969-71. doi: 10.1016/s1097-2765(02)00754-2.

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.

Genes Dev. 1999 Aug 15;13(16):2059-71. doi: 10.1101/gad.13.16.2059.

[Signal transduction of Toll-like receptors].

Nihon Rinsho. 2005 Apr;63 Suppl 4:109-14.

Toll-like receptors as adjuvant receptors.

Biochim Biophys Acta. 2002 Feb 13;1589(1):1-13. doi: 10.1016/s0167-4889(01)00182-3.

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

J Exp Med. 2000 Aug 21;192(4):595-600. doi: 10.1084/jem.192.4.595.

Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.

J Immunol. 1999 Jul 15;163(2):639-43.

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Innate immune induction of the adaptive immune response.

作者信息

Medzhitov R, Janeway C A

机构信息

Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520-8011, USA.

出版信息

Cold Spring Harb Symp Quant Biol. 1999;64:429-35. doi: 10.1101/sqb.1999.64.429.

DOI:10.1101/sqb.1999.64.429

PMID:11232318

Abstract

摘要

相似文献

Innate immune induction of the adaptive immune response.

Cold Spring Harb Symp Quant Biol. 1999;64:429-35. doi: 10.1101/sqb.1999.64.429.

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Nature. 2002 Nov 21;420(6913):329-33. doi: 10.1038/nature01180.

Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta.

Biochem Biophys Res Commun. 2003 Feb 7;301(2):495-501. doi: 10.1016/s0006-291x(02)03082-6.

NF-kappa B activation by tumor necrosis factor and interleukin-1.

Cold Spring Harb Symp Quant Biol. 1999;64:473-83. doi: 10.1101/sqb.1999.64.473.

Wanted: a molecular basis for specificity in toll-like receptor signal transduction.

Mol Cell. 2002 Nov;10(5):969-71. doi: 10.1016/s1097-2765(02)00754-2.

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.

Genes Dev. 1999 Aug 15;13(16):2059-71. doi: 10.1101/gad.13.16.2059.

[Signal transduction of Toll-like receptors].

Nihon Rinsho. 2005 Apr;63 Suppl 4:109-14.

Toll-like receptors as adjuvant receptors.

Biochim Biophys Acta. 2002 Feb 13;1589(1):1-13. doi: 10.1016/s0167-4889(01)00182-3.

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

J Exp Med. 2000 Aug 21;192(4):595-600. doi: 10.1084/jem.192.4.595.

Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.

J Immunol. 1999 Jul 15;163(2):639-43.

引用本文的文献

Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications.

Theranostics. 2025 Jul 25;15(16):8222-8258. doi: 10.7150/thno.116951. eCollection 2025.

Targeted release of a bispecific fusion protein SIRPα/Siglec-10 by oncolytic adenovirus reinvigorates tumor-associated macrophages to improve therapeutic outcomes in solid tumors.

J Immunother Cancer. 2025 Apr 1;13(4):e010767. doi: 10.1136/jitc-2024-010767.

Harnessing Senescence for Antitumor Immunity to Advance Cancer Treatment.

Radiat Res. 2024 Nov 1;202(5):727-733. doi: 10.1667/RADE-24-00098.1.

Targeting Innate Immunity in Glioma Therapy.

Int J Mol Sci. 2024 Jan 12;25(2):947. doi: 10.3390/ijms25020947.

Targeting innate immune pathways for cancer immunotherapy.

Immunity. 2023 Oct 10;56(10):2206-2217. doi: 10.1016/j.immuni.2023.07.018. Epub 2023 Sep 12.

Spotlight on NLRP6 and Tumor Research Situation: A Potential Cancer Participant.

J Immunol Res. 2023 Jun 28;2023:6613064. doi: 10.1155/2023/6613064. eCollection 2023.

Neutrophil S100A9 supports M2 macrophage niche formation in granulomas.

iScience. 2023 Jan 31;26(3):106081. doi: 10.1016/j.isci.2023.106081. eCollection 2023 Mar 17.

Innate Immune Memory and the Host Response to Infection.

J Immunol. 2022 Feb 15;208(4):785-792. doi: 10.4049/jimmunol.2101058.

Inflammation and tumor progression: signaling pathways and targeted intervention.

Signal Transduct Target Ther. 2021 Jul 12;6(1):263. doi: 10.1038/s41392-021-00658-5.

A spontaneous multifunctional hydrogel vaccine amplifies the innate immune response to launch a powerful antitumor adaptive immune response.

Theranostics. 2021 May 8;11(14):6936-6949. doi: 10.7150/thno.58173. eCollection 2021.

Innate immune induction of the adaptive immune response.

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Innate immune induction of the adaptive immune response.

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