Guilhermetti M, Hernandes S E, Fukushigue Y, Garcia L B, Cardoso C L
Department of Clinical Analyses, State University of Maringá, Paraná, Brazil.
Infect Control Hosp Epidemiol. 2001 Feb;22(2):105-8. doi: 10.1086/501872.
The effectiveness of hand-cleansing agents in removing a hospital strain of methicillin-resistant Staphylococcus aureus from artificially contaminated hands of five volunteers was studied.
The products used were plain liquid soap, ethyl alcohol 70% (by weight), 10% povidone-iodine liquid soap (PVP-I), and chlorhexidine gluconate (4%) detergent. The experiments were performed using a Latin square statistical design, with two 5x4 randomized blocks. The removal rates of S aureus cells from contaminated fingertips were estimated by analysis of variance, the response variable being the log10 reduction factor (RF), ie, log10 of the initial counts minus log10 of the final counts. In the first and second blocks, the fingertips of the volunteers were contaminated in mean with 3.76 log10 colony-forming units ([CFU] light-contamination hand) and 6.82 log10 CFU (heavy-contamination hand), respectively.
In the first block, there were significant differences between treatments (P<.05). The 10% PVP-I (RF, 3.76) and 70% ethyl alcohol (RF, 3.51) had significantly higher removal rates than plain liquid soap (RF, 1.96) and 4% chlorhexidine (RF, 1.91). In the second block, 10% PVP-I (RF, 4.39) and 70% ethyl alcohol (RF, 3.27) also were significantly more effective than plain liquid soap (RF, 1.77) and 4% chlorhexidine (RF, 1.37; P<.05). Plain liquid soap was significantly more effective than chlorhexidine (4%) detergent.
The results suggest that 10% PVP-I and 70% ethyl alcohol may be the most effective hand-cleansing agents for removing methicillin-resistant S aureus strain from either lightly or heavily contaminated hands.
研究手部清洁制剂对从五名志愿者人工污染的手上清除医院分离的耐甲氧西林金黄色葡萄球菌的有效性。
使用的产品有普通液体肥皂、70%（重量）乙醇、10%聚维酮碘液体肥皂（PVP-I）和葡萄糖酸洗必泰（4%）洗涤剂。实验采用拉丁方统计设计，有两个5×4随机区组。通过方差分析估计从污染指尖清除金黄色葡萄球菌细胞的速率，反应变量为log10减少因子（RF），即初始计数的log10减去最终计数的log10。在第一个和第二个区组中，志愿者的指尖平均分别被污染3.76 log10菌落形成单位（[CFU]轻度污染手）和6.82 log10 CFU（重度污染手）。
在第一个区组中，各处理之间存在显著差异（P<0.05）。10% PVP-I（RF，3.76）和70%乙醇（RF，3.51）的清除率显著高于普通液体肥皂（RF，1.96）和4%洗必泰（RF，1.91）。在第二个区组中，10% PVP-I（RF，4.39）和70%乙醇（RF，3.27）也比普通液体肥皂（RF，1.77）和4%洗必泰（RF，1.37；P<0.05）显著更有效。普通液体肥皂比4%洗必泰洗涤剂显著更有效。
结果表明，10% PVP-I和70%乙醇可能是从轻度或重度污染的手上清除耐甲氧西林金黄色葡萄球菌菌株最有效的手部清洁制剂。
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