Tatlidil R, Luther S, West A, Jadvar H, Kingman T
Research Imaging Center and Division of Neurosurgery, University of Texas Health Science Center, San Antonio, USA.
Acta Neurol Belg. 2000 Dec;100(4):214-20.
This study reports a comparison of Fluorine-18 deoxyglucose positron emission tomography (FDG-PET) and O-15 water (H2(15)O) PET with regard to lateralization of the seizure focus in patients with complex partial epilepsy. The analysis of 35 patients who had an anterior temporal lobectomy for medically intractable seizures indicated that FDG- and H2(15)O-PET were highly correlated in demonstrating the epileptic focus. FDG- and H2(15)O-PET showed significant asymmetries in 83% and 77% of cases respectively. The lateralization with visual analysis of MRI was found to be lower than both FDG and blood flow imaging. Ictal electroencephalography (EEG) lateralizations were concordant with sites of blood flow and FDG-PET abnormalities. Thirty-three patients (94%) were seizure-free or improved significantly after surgery. In conclusion, blood flow PET yielded similar results compared to FDG-PET and can be a valuable modality in preoperative evaluation of patients with temporal lobe epilepsy.
本研究报告了氟-18脱氧葡萄糖正电子发射断层扫描（FDG-PET）和氧-15水（H2(15)O）PET在复杂部分性癫痫患者癫痫发作灶定位方面的比较。对35例因药物难治性癫痫接受前颞叶切除术的患者进行分析表明，FDG-PET和H2(15)O-PET在显示癫痫病灶方面高度相关。FDG-PET和H2(15)O-PET分别在83%和77%的病例中显示出显著的不对称性。发现MRI视觉分析的定位低于FDG和血流成像。发作期脑电图（EEG）定位与血流和FDG-PET异常部位一致。33例患者（94%）术后无癫痫发作或明显改善。总之，血流PET与FDG-PET产生相似的结果，并且在颞叶癫痫患者的术前评估中可能是一种有价值的检查方法。
