da Silva V D, Prolla J C, Sharma P, Sampliner R, Thompson D, Bartels P H
Department of Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Anal Quant Cytol Histol. 2001 Feb;23(1):40-6.
To derive a progression curve for lesions in Barrett's esophagus based on karyometric features.
High-resolution imagery of 900 nuclei from normal gastric tissue, Barrett's metaplasia, Barrett's high grade dysplasia and adenocarcinoma of the esophagus was recorded. Karyometric features were computed, and nuclear signatures and lesion signatures for these lesions were derived. A progression curve was defined.
Esophageal lesions were distinctly different from the normal gastric fundus tissue, with nuclei from Barrett's metaplasia deviating from normal almost as much as nuclei from high grade dysplasia and adenocarcinoma. There was considerable case-to-case variability and overlap between lesions histologically assigned to different diagnostic categories.
The karyometric data suggest that Barrett's metaplasia is a more developed lesion than previously assumed.
基于核测量特征推导巴雷特食管病变的进展曲线。
记录了来自正常胃组织、巴雷特化生、巴雷特高级别异型增生和食管腺癌的900个细胞核的高分辨率图像。计算核测量特征，并得出这些病变的核特征和病变特征。定义了一条进展曲线。
食管病变与正常胃底组织明显不同，巴雷特化生的细胞核与正常细胞核的差异几乎与高级别异型增生和腺癌的细胞核相同。在组织学上归为不同诊断类别的病变之间存在相当大的病例间变异性和重叠。
核测量数据表明，巴雷特化生是一种比先前认为的更严重的病变。
