Sieling P A, Modlin R L
Department of Medicine, Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095, USA.
Scand J Infect Dis. 2001;33(2):97-100. doi: 10.1080/003655401750065454.
In Drosophila, the Toll family of proteins are central to innate defense against microbial pathogens. Conserved throughout evolution, mammalian Toll-like receptors (TLRs) participate in innate immunity. TLRs mediate activation by microbial ligands including lipoproteins, resulting in the activation of IL-12 and nitric oxide synthase. Microbial lipoproteins also induce host cell apoptosis. In this manner, the ability of microbial lipoproteins to activate TLRs can contribute to host defense and immunopathology during infection.
在果蝇中，Toll蛋白家族对于抵御微生物病原体的先天性防御至关重要。在整个进化过程中保守存在的哺乳动物Toll样受体（TLR）参与先天性免疫。TLR由包括脂蛋白在内的微生物配体介导激活，从而导致白细胞介素-12和一氧化氮合酶的激活。微生物脂蛋白还可诱导宿主细胞凋亡。通过这种方式，微生物脂蛋白激活TLR的能力在感染过程中有助于宿主防御和免疫病理学。
