Naccarelli G V, Wolbrette D L, Luck J C
Department of Medicine, Pennsylvania State University College of Medicine, Milton Hershey Medical Center, Hershey, Pennsylvania, USA.
Med Clin North Am. 2001 Mar;85(2):503-26, xii. doi: 10.1016/s0025-7125(05)70324-2.
Proarrhythmia is defined as the aggravation of an existing arrhythmia or the development of a new arrhythmia secondary to antiarrhythmic drug. Proarrhythmic events include drug-induced bradyarrhythmias, atrial and ventricular proarrhythmias. New onset sustained or incessant ventricular tachycardia and torsade de pointes can be life threatening. This article reviews the incidence, aggravating factors, and treatment of proarrhythmia.
致心律失常作用被定义为已存在的心律失常加重或继发于抗心律失常药物的新心律失常的发生。致心律失常事件包括药物诱发的缓慢性心律失常、房性和室性致心律失常作用。新发生的持续性或无休止性室性心动过速及尖端扭转型室速可能危及生命。本文综述了致心律失常作用的发生率、加重因素及治疗。
