Sladowska H, Szkatuła D, Filipek B, Maciag D, Sapa J, Zygmunt M
Department of Chemistry of Drugs, Wrocław University of Medicine, Kraków, Poland.
Pharmazie. 2001 Feb;56(2):133-8.
The synthesis of 2-(4-substituted)butyl derivatives of 4-alkoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (10-15) and the results of preliminary pharmacological screening are described in this paper. All the compounds tested showed a strong analgesic action, suppressed spontaneous locomotor activity and prolonged barbiturate sleep. Except 10, all significantly decreased systolic and diastolic blood pressure.
