2,4-二取代5-氨基-6-嘧啶羧酸衍生物的合成及药理性质。第三部分。
Synthesis and pharmacological properties of 2,4-disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives. Part III.
作者信息
Jasztold-Howorko R, Machoń Z, Wilimowski M, Wojewódzki W, Barczyńska J, Kedzierska L, Orzechowska-Juzwenko K, Duś E, Dziewiszek W, Rutkowska M
机构信息
Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
出版信息
Pol J Pharmacol. 1995 Sep-Oct;47(5):435-40.
PMID:8868136
Abstract
2,4-Disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives 5-13 were synthesized and evaluated for their pharmacological activity. Compounds 5, 7, 9, 10 and 12 showed antiaggressive effect, compounds 6 and 10 showed synergism with hexobarbital while compound 6 exerted analgesic activity.
摘要
合成了2,4-二取代的5-氨基-6-嘧啶羧酸衍生物5-13，并对其药理活性进行了评估。化合物5、7、9、10和12显示出抗攻击作用，化合物6和10与己巴比妥有协同作用，而化合物6具有镇痛活性。
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