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[肝素和达那肝素加重血小板减少]

[Thrombopenia increased by heparin and danaparoid].

作者信息

Godet G, Bertrand M, Van de Steen E, Boccara G, Koskas F

机构信息

Département d'anesthésie-réanimation, hôpital Pitié-Salpêtrière, 75013 Paris, France.

出版信息

Ann Fr Anesth Reanim. 2001 Jan;20(1):50-3. doi: 10.1016/s0750-7658(00)00333-6.

DOI:10.1016/s0750-7658(00)00333-6
PMID:11234580
Abstract

Pathogenesis, frequency, and management of heparin-induced thrombocytopaenia are well-known. They may be related with both unfractioned heparin and low-molecular weight heparin. Suspected heparin must be discontinued as soon as the diagnosis is established. Orgaran (danaparoid sodium) may be used for management of patients with heparin-associated thrombocytopaenia but can itself be associated with a thrombocytopaenia. Our case report allows us to catch in mind such a crossed complication.

摘要

肝素诱导的血小板减少症的发病机制、发生率及处理方法已为人熟知。它与普通肝素和低分子肝素均有关。一旦确诊,必须立即停用可疑的肝素。奥加诺(达那肝素钠)可用于治疗肝素相关性血小板减少症患者,但它本身也可能与血小板减少症有关。我们的病例报告让我们记住了这样一种交叉并发症。

相似文献

1
[Thrombopenia increased by heparin and danaparoid].[肝素和达那肝素加重血小板减少]
Ann Fr Anesth Reanim. 2001 Jan;20(1):50-3. doi: 10.1016/s0750-7658(00)00333-6.
2
Coagulation complicating cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia receiving the heparinoid, danaparoid sodium.一名接受类肝素药物达那肝素钠治疗的肝素诱导性血小板减少症患者在体外循环时发生凝血并发症。
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3
Orgaran (Org 10172) for cardiopulmonary bypass in heparin-induced thrombocytopenia: role of adjunctive plasmapheresis.奥加兰(Org 10172)在肝素诱导的血小板减少症患者体外循环中的应用:辅助性血浆置换的作用
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4
In vitro cross-reactivity of danaparoid sodium in patients with heparin-induced thrombocytopenia type II undergoing cardiovascular surgery.
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5
Use of danaparoid sodium (Orgaran) as an alternative to heparin sodium during cardiopulmonary bypass: a clinical evaluation of six cases.在体外循环期间使用达那肝素钠(奥加诺)替代肝素钠:6例临床评估。
Perfusion. 2000 Nov;15(6):531-9. doi: 10.1177/026765910001500610.
6
Thrombosis during the use of the heparinoid Organon 10172 in a patient with heparin-induced thrombocytopenia.在一名肝素诱导的血小板减少症患者使用类肝素药物Organon 10172期间发生血栓形成。
Anesthesiology. 1997 Feb;86(2):495-8. doi: 10.1097/00000542-199702000-00026.
7
Danaparoid for heparin-induced thrombocytopenia: an analysis of treatment failures.达那肝素治疗肝素诱导的血小板减少症:治疗失败分析
Eur J Haematol. 2003 Aug;71(2):109-13. doi: 10.1034/j.1600-0609.2003.00105.x.
8
Fatal danaparoid-sodium induced thrombocytopenia and arterial thromboses.达那帕罗钠导致的致命性血小板减少症和动脉血栓形成。
Thromb Haemost. 1998 Sep;80(3):530.
9
Heparin-induced thrombocytopenia: cross-reactivity between standard heparin, low molecular weight heparin, dalteparin (Fragmin) and heparinoid, danaparoid (Orgaran).
Br J Haematol. 1995 Nov;91(3):736-8. doi: 10.1111/j.1365-2141.1995.tb05377.x.
10
Lifesaving citrate anticoagulation to bridge ineffective danaparoid [correction of to bridge to danaparoid] treatment.使用挽救生命的枸橼酸盐抗凝法来衔接达那肝素治疗无效的情况。
Ann Thorac Surg. 2002 May;73(5):1626-7. doi: 10.1016/s0003-4975(01)03438-5.