Aroniadou-Anderjaska V, Post R M, Rogawski M A, Li H
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Neuroreport. 2001 Mar 5;12(3):635-40. doi: 10.1097/00001756-200103050-00041.
The amygdala plays a central role in emotional memory. The cellular mechanisms by which the amygdala participates in emotional learning are believed to be changes in efficacy of synaptic transmission, similar to long-term potentiation (LTP) and long-term depression (LTD). Although different forms of LTP have been shown in the amygdala, many of their features are still unknown. Here, we use both field potential and intracellular recordings in rat amygdala slices, and show that LTP in the basolateral nucleus, induced by high-frequency stimulation (HFS) of the external capsule is input-specific, can be reversed by low-frequency stimulation (LFS), and can be reinstated by HFS. These synapse-specific, reversible changes in synaptic strength in the basolateral nucleus of the amygdala may be important to amygdala's role in emotional memory.
杏仁核在情绪记忆中起着核心作用。杏仁核参与情绪学习的细胞机制被认为是突触传递效能的变化，类似于长时程增强（LTP）和长时程抑制（LTD）。尽管在杏仁核中已显示出不同形式的LTP，但其许多特征仍不清楚。在这里，我们在大鼠杏仁核切片中同时使用场电位和细胞内记录，并表明由外囊高频刺激（HFS）诱导的基底外侧核中的LTP是输入特异性的，可以被低频刺激（LFS）逆转，并且可以被HFS恢复。杏仁核基底外侧核中这些突触特异性、可逆的突触强度变化可能对杏仁核在情绪记忆中的作用很重要。
