Storey P A, Bugri S, Magnussen P, Polderman A M
Department of Parasitology, Leids Universitair Medisch Centrum, P.O. Box 9600, 2300RC Leiden, The Netherlands.
Ann Trop Med Parasitol. 2001 Jan;95(1):87-95. doi: 10.1080/00034980020035951.
Ultrasonography has already revealed that up to 50% of individuals in some villages in northern Ghana have colonic pathology induced by Oesophagostomum bifurcum. Approximately 2% of those affected progress to clinical oesophagostomiasis if left untreated. In the present study, ultrasound-positive children living in a heavily infected community were each given 5 days of treatment with albendazole (10 mg/kg.day), early in the dry season. Treatment reduced the prevalence, number, size and half-life of the ultrasound-visible nodules, stopped the excretion of O. bifurcum eggs, and reduced the development of clinical oesophagostomiasis during the subsequent 8 months. However, the treatment had no impact on the new infections that occurred during the following rainy season, and no impact on nodule prevalence by the end of that rainy season. Surgical management may not be essential in non-acute cases of clinical oesophagostomiasis, as albendazole may kill the nodule-dwelling worms.
超声检查已经显示，在加纳北部的一些村庄，高达50%的人患有由分支食道口线虫引起的结肠病变。如果不进行治疗，大约2%的感染者会发展为临床食道口线虫病。在本研究中，生活在感染严重社区的超声检查呈阳性的儿童，在旱季早期均接受了5天的阿苯达唑治疗（10毫克/千克·天）。治疗降低了超声可见结节的患病率、数量、大小和半衰期，停止了分支食道口线虫卵的排泄，并在随后的8个月内减少了临床食道口线虫病的发生。然而，该治疗对接下来雨季期间发生的新感染没有影响，到该雨季结束时对结节患病率也没有影响。对于临床食道口线虫病的非急性病例，手术治疗可能并非必不可少，因为阿苯达唑可能会杀死寄生于结节中的蠕虫。
