Rémita S
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Unité Mixte de Recherche 8601, Centre National de la Recherche Scientifique, Université Paris V, France.
Can J Physiol Pharmacol. 2001 Feb;79(2):144-53.
Lipids are the essential components of cell membranes and lipoproteins. Their peroxidation plays an important role in numerous pathologies in which oxidative stress is involved. Lipid peroxidation occurs through a chain reaction that contributes to membrane damage in cells. It results in the conversion of fatty acids to polar hydroperoxides and leads to the breakdown or malfunction of the membrane. Lipids are amphiphilic molecules that aggregate in aqueous solutions into micelles and liposomes. The effect of this structural organization is significant in studies of radiation-induced peroxidation damage in highly ordered biological systems such as biological membranes. In this paper, a synthesis of the data concerning radioinduced lipid peroxidation is completed by an original review of the different parameters that determine lipid oxidizability. In addition, the influence of lipid aggregation and the effect of molecular packing are discussed.
脂质是细胞膜和脂蛋白的重要组成部分。其过氧化作用在众多涉及氧化应激的病理过程中发挥着重要作用。脂质过氧化通过链式反应发生，该反应会导致细胞中的膜损伤。它会使脂肪酸转化为极性氢过氧化物，并导致膜的破裂或功能异常。脂质是两亲性分子，在水溶液中会聚集形成胶束和脂质体。这种结构组织的效应在诸如生物膜等高度有序的生物系统中辐射诱导的过氧化损伤研究中具有重要意义。在本文中，通过对决定脂质氧化能力的不同参数进行原创性综述，完成了有关辐射诱导脂质过氧化数据的综合。此外，还讨论了脂质聚集的影响以及分子堆积的效应。
