Stone S, Khamashta M A, Poston L
Lupus Pregnancy Clinic, St Thomas' Hospitals, London, UK.
Lupus. 2001;10(2):67-74. doi: 10.1191/096120301667486047.
The antiphospholipid antibodies (aPLs) are a diverse group of autoantibodies associated with a pattern of disease known as antiphospholipid syndrome (APS). Pregnancy complications secondary to placental insufficiency are key features of this disease. The mechanisms underlying the placental pathology remain unclear. In this article the process of placentation in healthy and pathological pregnancies is reviewed. The evidence for defective placentation in APS pregnancies and involvement of aPLs in this process is summarized. Finally hypotheses based on the interpretation of these studies are discussed.
抗磷脂抗体（aPLs）是一组多样的自身抗体，与一种称为抗磷脂综合征（APS）的疾病模式相关。胎盘功能不全继发的妊娠并发症是该疾病的关键特征。胎盘病理的潜在机制仍不清楚。本文综述了正常妊娠和病理妊娠中的胎盘形成过程。总结了APS妊娠中胎盘形成缺陷以及aPLs参与这一过程的证据。最后讨论了基于这些研究解读的假设。
