Osmundsen H, Clouet P
Department of Physiology and Biochemistry, Institute for Oral Biology, University of Oslo, Norway.
Biofactors. 2000;13(1-4):5-8. doi: 10.1002/biof.5520130102.
Some metabolic effects of dietary marine oils, or of dietary eicosapentaenoic or docosahexaenoic acid are reviewed. It is pointed out that docosahexaenoic acid appears more effective as regards induction of peroxisomal beta-oxidation. Similarly, docosahexaenoic appears more powerful in terms of suppression of hepatic delta9-desaturase activity and mRNA-levels. The potential inhibitory effect of polyunsaturated fatty acids, particularly docosahexaenoic acid, on mitochondrial beta-oxidation is discussed. Experiments with rats suggesting that the hypolipidaemic response of eicosapentaenoic acid is more marked when the fatty acid was given to fed rats, as compared to fasted rats, are discussed.
本文综述了膳食海洋油、二十碳五烯酸或二十二碳六烯酸的一些代谢效应。指出二十二碳六烯酸在诱导过氧化物酶体β-氧化方面似乎更有效。同样，二十二碳六烯酸在抑制肝脏Δ9-去饱和酶活性和mRNA水平方面似乎更强。讨论了多不饱和脂肪酸，特别是二十二碳六烯酸对线粒体β-氧化的潜在抑制作用。还讨论了用大鼠进行的实验，这些实验表明，与禁食大鼠相比，给进食的大鼠喂食二十碳五烯酸时，其降血脂反应更明显。
