Vogel D
Ross University School of Medicine, Portsmouth, Commonwealth of Dominica, Windward Islands.
Brain Cogn. 2001 Mar;45(2):212-28. doi: 10.1006/brcg.2000.1238.
Mammalian memory is commonly "explained" in terms of long-term potentiation (LTP) of excitatory synapses. However, depotentiation of inhibitory pathways (disinhibition) is also a known phenomenon in the brain. Artificial neural networks which are offered as partial models of the cerebrum traditionally encode memory by the potentiation of excitatory "synapses" in a manner which is thought of as analogous to LTP. Analysis shows that such models have seriously limited storage capacities. The models also depend on mechanisms which do not appear to be biologically plausible. This paper demonstrates that these difficulties are avoided by encoding memory by means of disinhibition rather than LTP. The resulting models are simple and plausible, though unconventional.
哺乳动物的记忆通常用兴奋性突触的长时程增强（LTP）来“解释”。然而，抑制性通路的去增强（去抑制）在大脑中也是一种已知现象。作为大脑部分模型的人工神经网络传统上通过增强兴奋性“突触”来编码记忆，其方式被认为类似于LTP。分析表明，这类模型的存储能力严重受限。这些模型还依赖于一些似乎在生物学上不太合理的机制。本文表明，通过去抑制而非LTP来编码记忆可以避免这些困难。由此产生的模型虽然非传统，但简单且合理。
