Goosens Ki A, Maren Stephen
Department of Psychology, University of Michigan, Ann Arbor 48109-1109, USA.
Hippocampus. 2002;12(5):592-9. doi: 10.1002/hipo.10099.
Recent reports have raised concerns about the ability of long-term potentiation (LTP) to account for associative learning and memory. In this paper, we review the many mechanistic similarities between one form of associative learning, Pavlovian fear conditioning, and amygdaloid LTP. We then address many of the criticisms levied against LTP within the framework of fear conditioning. We believe that many of the apparent discrepancies between LTP and behavior can be generally accounted for by a failure to appreciate that learned behavior is supported by multiple synapses in an extensive network of brain structures. We conclude that LTP remains a viable substrate for memory.
最近的报告引发了人们对长时程增强（LTP）能否解释联想学习和记忆的担忧。在本文中，我们回顾了一种联想学习形式——巴甫洛夫恐惧条件反射与杏仁核LTP之间的许多机制相似性。然后，我们在恐惧条件反射的框架内回应了针对LTP提出的许多批评。我们认为，LTP与行为之间许多明显的差异，通常可以通过未能认识到习得行为是由广泛的脑结构网络中的多个突触支持来解释。我们得出结论，LTP仍然是记忆的一个可行基础。
