Chiwakata C B, Manegold C, Bönicke L, Waase I, Jülch C, Dietrich M
Department of Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
J Infect Dis. 2001 Apr 1;183(7):1161-4. doi: 10.1086/319283. Epub 2001 Mar 1.
The serum levels of procalcitonin (PCT) in Plasmodium falciparum malaria were evaluated for clinical significance in 66 nonimmune and semi-immune patients. Of the 66 patients, 36 had uncomplicated malaria, 24 had severe and complicated malaria, and 6 had fatal malaria (5 from previous studies). Pretreatment PCT concentrations were closely correlated with parasitemia. Concentrations were lowest in semi-immune patients with uncomplicated malaria, compared with those in nonimmune patients (geometric mean concentrations [GMCs], 1.07 and 2.37 ng/mL, respectively), and were highest in severe and complicated cases (GMC, 10.67 ng/mL; P<.001 among all subgroups). Six of 7 patients with PCT concentrations >25 ng/mL died. PCT concentrations decreased on day 2 of treatment in survivors but not in patients with fatal outcome. Thus, repeated PCT measurements may provide useful prognostic information, especially in medical centers that are not experienced in parasite density determination.
对66例非免疫和半免疫的恶性疟患者的降钙素原（PCT）血清水平进行了评估，以探讨其临床意义。66例患者中，36例为非复杂性疟疾，24例为严重和复杂性疟疾，6例为致命性疟疾（5例来自先前研究）。治疗前PCT浓度与疟原虫血症密切相关。与非免疫患者相比，半免疫非复杂性疟疾患者的浓度最低（几何平均浓度[GMC]分别为1.07和2.37 ng/mL），严重和复杂性病例中的浓度最高（GMC为10.67 ng/mL；所有亚组之间P<0.001）。PCT浓度>25 ng/mL的7例患者中有6例死亡。幸存者治疗第2天时PCT浓度下降，但致命结局患者则不然。因此，重复测量PCT可能提供有用的预后信息，尤其是在没有寄生虫密度测定经验的医疗中心。
