给予L-阿拉伯糖可防止大鼠因膳食蔗糖导致的生脂酶和三酰甘油水平升高。

L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats.

作者信息

Osaki S, Kimura T, Sugimoto T, Hizukuri S, Iritani N

机构信息

Faculty of Human and Cultural Studies, Tezukayama Gakuin University Sakai, Osaka 590-0113, Japan.

出版信息

J Nutr. 2001 Mar;131(3):796-9. doi: 10.1093/jn/131.3.796.

DOI:10.1093/jn/131.3.796

PMID:11238761

Abstract

L-Arabinose is a natural, poorly absorbed pentose that selectively inhibits intestinal sucrase activity. To investigate the effects of L-arabinose feeding on lipogenesis due to its inhibition of sucrase, rats were fed 0-30 g sucrose/100 g diets containing 0-1 g L-arabinose/100 g for 10 d. Lipogenic enzyme activities and triacylglycerol concentrations in the liver were significantly increased by dietary sucrose, and arabinose significantly prevented these increases. Arabinose feeding reduced the weights of epididymal adipose tissue. Moreover, plasma insulin and triacylglycerol concentrations were significantly reduced by dietary L-arabinose. These findings suggest that L-arabinose inhibits intestinal sucrase activity, thereby reducing sucrose utilization, and consequently decreasing lipogenesis.

摘要

L-阿拉伯糖是一种天然的、吸收性差的戊糖，它能选择性抑制肠道蔗糖酶活性。为研究L-阿拉伯糖通过抑制蔗糖酶对脂肪生成的影响，给大鼠喂食含0 - 1克L-阿拉伯糖/100克且蔗糖含量为0 - 30克/100克的日粮，持续10天。日粮中的蔗糖显著增加了肝脏中脂肪生成酶的活性和甘油三酯浓度，而阿拉伯糖显著抑制了这些增加。喂食阿拉伯糖可减轻附睾脂肪组织的重量。此外，日粮中的L-阿拉伯糖显著降低了血浆胰岛素和甘油三酯浓度。这些发现表明，L-阿拉伯糖抑制肠道蔗糖酶活性，从而减少蔗糖利用，进而降低脂肪生成。