Preuss Harry G, Echard Bobby, Bagchi Debasis, Stohs Sidney
Georgetown University Medical Center, Department of Physiology, Washington, DC 20057, USA.
Int J Med Sci. 2007 Aug 10;4(4):209-15. doi: 10.7150/ijms.4.209.
Acute oral consumption of various natural inhibitors of amylase (bean and hibiscus extracts) and sucrase (L-arabinose) reduce absorption of starch and sucrose respectively in rats and pigs measured by lessened appearance of circulating glucose levels. The present subchronic study was designed to determine whether these selected inhibitors of gastrointestinal starch and sucrose absorption (so-called "carb blockers") remain effective with continued use and to assess their metabolic influences after prolonged intake. Sprague-Dawley rats were gavaged twice daily over nine weeks with either water or an equal volume of water containing a formula that included bean and hibiscus extracts and L-arabinose. To estimate CHO absorption, control and treated Sprague-Dawley rats were gavaged with either water alone or an equal volume of water containing glucose, rice starch, sucrose, or combined rice starch and sucrose. Circulating glucose was measured at timed intervals over four hours. The ability to decrease starch and sucrose absorption use. No toxic effects (hepatic, renal, hematologic) were evident. Blood chemistries revealed significantly lower circulating glucose levels and a trend toward decreased HbA1C in the nondiabetic rats receiving the natural formulation compared to control. Subchronic administration of enzyme inhibitors was also associated with many metabolic changes including lowered systolic blood pressure and altered fluid-electrolyte balance. We postulate that proper intake of natural amylase and sucrase inhibitors may be useful in the prevention and treatment of many chronic disorders associated with perturbations in glucose-insulin homeostasis secondary to the rapid absorption of refined CHO.
急性经口摄入各种淀粉酶天然抑制剂（豆类和木槿提取物）和蔗糖酶抑制剂（L-阿拉伯糖），通过循环葡萄糖水平出现减少来衡量，分别降低了大鼠和猪对淀粉和蔗糖的吸收。本亚慢性研究旨在确定这些选定的胃肠道淀粉和蔗糖吸收抑制剂（所谓的“碳水化合物阻滞剂”）持续使用是否仍然有效，并评估长期摄入后它们的代谢影响。将斯普拉格-道利大鼠每天两次灌胃，持续九周，灌胃物为水或等体积含豆类和木槿提取物以及L-阿拉伯糖配方的水。为了估计碳水化合物的吸收，给对照和处理过的斯普拉格-道利大鼠单独灌胃水或等体积含葡萄糖、大米淀粉、蔗糖或大米淀粉与蔗糖混合物的水。在四个小时内定时测量循环葡萄糖。降低淀粉和蔗糖吸收的能力得以体现。未发现明显的毒性作用（肝脏、肾脏、血液学方面）。血液化学检测显示，与对照组相比，接受天然配方的非糖尿病大鼠循环葡萄糖水平显著降低，糖化血红蛋白A1C有下降趋势。酶抑制剂的亚慢性给药还与许多代谢变化有关，包括收缩压降低和水电解质平衡改变。我们推测，适当摄入天然淀粉酶和蔗糖酶抑制剂可能有助于预防和治疗许多与精制碳水化合物快速吸收继发的葡萄糖-胰岛素稳态紊乱相关的慢性疾病。
