Krivoruchenko I V, Ianushkene T S
Kardiologiia. 1975 Feb;15(2):78-84.
Diurnal fluctuations in the level of cholesterol, phospholipids, triglycerides, NEFA and sugar in the blood of practically healthy subjects and in patients with ischemic heart disease, attended by hyperlipoproteinemia of the II and IV types, were studied. Investigations were made at 9 a.m., 3 and 9 p.m. The variations of the lipid fractions and sugar in the blood of practically healthy individuals and of patients with hyperlipoproteinemia showed no essential differences. There were minimal diurnal changes in the cholesterol level, a tendency towards an increase in the level of phospholipids, a statistically significant rise in the content of triglycerides and sugar in the blood and large fluctuations in the level of the NEFA, both upwards and downwards. In patients with hyperlipoproteinemia of the II type variations in the blood cholesterol and phospholipids levels occurring in the course of the day proved to be of the same nature as in the case of normal lipoproteinemia, with no diurnal rise of the sugar level, while the NEFA content showed a distinct upward tendency. In patients it was only the blood cholesterol and triglycerides level that remained at a statistically significant higher level throughout the day.
对实际健康受试者以及患有缺血性心脏病且伴有II型和IV型高脂蛋白血症患者血液中胆固醇、磷脂、甘油三酯、非酯化脂肪酸（NEFA）和糖水平的昼夜波动情况进行了研究。研究于上午9点、下午3点和9点进行。实际健康个体和高脂蛋白血症患者血液中脂质成分和糖的变化没有本质区别。胆固醇水平昼夜变化最小，磷脂水平有升高趋势，血液中甘油三酯和糖含量有统计学意义的升高，非酯化脂肪酸水平波动较大，有升有降。在II型高脂蛋白血症患者中，一天中血液胆固醇和磷脂水平的变化与正常脂蛋白血症情况相同，血糖水平无昼夜升高，而非酯化脂肪酸含量有明显上升趋势。在患者中，一整天只有血液胆固醇和甘油三酯水平在统计学上显著高于正常水平。
