Raymer A M, Bandy D, Adair J C, Schwartz R L, Williamson D J, Gonzalez Rothi L J, Heilman K M
Old Dominion University, Norfolk, VA, USA.
Arch Phys Med Rehabil. 2001 Jan;82(1):139-44. doi: 10.1053/apmr.2001.18056.
Because studies have shown some positive effects of the dopaminergic agent bromocriptine for improving verbal production in patients with nonfluent aphasia, we examined its effect in a patient with an atypical form of crossed nonfluent aphasia from a right hemisphere lesion.
Open-label single-subject experimental ABAB withdrawal design.
A right-handed man who, after a right frontal stroke, developed nonfluent aphasia, emotional aprosodia, and limb apraxia.
Escalating doses up to 20mg of bromocriptine in 2 separate phases.
We measured verbal fluency (words/min in discourse, Thurstone letter fluency), expression of emotional prosody, and gesture production.
The patient showed substantial improvement in both verbal fluency measures and no significant improvement in gesture or emotional prosody. Verbal fluency improvements continued in withdrawal phases.
Our results are less likely caused by practice or spontaneous recovery because we observed little improvement in emotional prosody and gesture tasks. Verbal fluency improvements during treatment and withdrawal phases suggest that the effects of bromocriptine may be long-lasting in its influence on the neural networks subserving verbal initiation.
由于研究表明多巴胺能药物溴隐亭对改善非流畅性失语患者的言语表达有一些积极作用，我们在一名因右侧半球病变导致非典型交叉性非流畅性失语的患者中研究了其效果。
开放标签单受试者实验性ABAB撤药设计。
一名右利手男性，在右侧额叶中风后出现非流畅性失语、情感性失韵律症和肢体失用症。
在两个不同阶段逐渐增加溴隐亭剂量至20毫克。
我们测量了言语流畅性（话语中的单词/分钟，瑟斯顿字母流畅性）、情感韵律表达和手势产生。
患者在两项言语流畅性测量中均有显著改善，而手势或情感韵律方面无显著改善。撤药阶段言语流畅性仍持续改善。
我们的结果不太可能是由练习或自发恢复引起的，因为我们在情感韵律和手势任务中观察到改善甚微。治疗阶段和撤药阶段言语流畅性的改善表明，溴隐亭对支持言语起始的神经网络的影响可能是持久的。
