Hirai K, Kumakiri M, Fujieda S, Sunaga H, Lao L M, Imamura Y, Ueda K, Fukuda M
Department of Dermatology, Fukui Medical University, Matsuoka, Shimoaizuki 23, Yoshida, 910-1193, Fukui, Japan.
J Dermatol Sci. 2001 Apr;25(3):179-88. doi: 10.1016/s0923-1811(00)00131-6.
Granulocyte colony-stimulating factor receptors (G-CSFR) have been observed on the surface of not only hematopoietic cells but also several cancer cells. In the present study, we investigated the expression of G-CSFR or G-CSF in epithelial skin tumors by immunohistochemical staining. The assessments were defined by the percentage of G-CSFR or G-CSF positive cells and expressed as G-CSFR and G-CSF scores. The G-CSFR score in SCC (77.6+/-20.0%) was significantly higher than that in Bowen's disease (BD) (51.0+/-35.6%), actinic keratosis (AK) (49.3+/-34.6%) or normal skin (30.0+/-32.1%) (P=0.0004, P=0.0003, P<0.0001, respectively). The mean G-CSF score in SCC (56.7+/-27.4%) or in BD (44.1+/-31.4%) was higher than that in normal skin (24.9+/-25.8%) (P=0.0075, P<0.001, respectively). G-CSF expression in AK (29.8+/-31.2%) was lower than that in SCC (P=0.0037). There was significant positive correlation between the G-CSFR score and the G-CSF score (gamma=0.274, P=0.0107) in skin tumors. These findings suggested that the assessment of G-CSFR expression might be associated with carcinogenesis of skin tumors.
粒细胞集落刺激因子受体（G-CSFR）不仅在造血细胞表面被观察到，在一些癌细胞表面也有发现。在本研究中，我们通过免疫组织化学染色研究了G-CSFR或G-CSF在上皮性皮肤肿瘤中的表达情况。评估通过G-CSFR或G-CSF阳性细胞的百分比来定义，并表示为G-CSFR和G-CSF评分。鳞状细胞癌（SCC）中的G-CSFR评分（77.6±20.0%）显著高于鲍恩病（BD）（51.0±35.6%）、光化性角化病（AK）（49.3±34.6%）或正常皮肤（30.0±32.1%）（分别为P=0.0004、P=0.0003、P＜０.0001）。SCC（56.7±27.4%）或BD（44.1±31.4%）中的平均G-CSF评分高于正常皮肤（24.9±25.8%）（分别为P=0.0075、P＜0.001）。AK中的G-CSF表达（29.8±31.2%）低于SCC（P=0.0037）。皮肤肿瘤中G-CSFR评分与G-CSF评分之间存在显著正相关（γ=0.274，P=0.0107）。这些发现表明，G-CSFR表达的评估可能与皮肤肿瘤的致癌作用有关。
