Lacaze-Masmonteil T, Thébaud B
Pédiatrie et Réanimation Néonatales, Hôpital Antoine-Béclère, AP/HP, 157, rue de la Porte-de-Trivaux, 92141 Clamart.
J Gynecol Obstet Biol Reprod (Paris). 2001 Feb;30(1 Suppl):21-6.
Despite improvement in neonatal care, the incidence of bronchopulmonary dysplasia has not decreased over the last decade. Moreover, chronic lung disease still occurs in very premature infants who do not require ventilatory support at birth. This review presents the growing body of epidemiological, experimental and clinical evidence suggesting that the occurrence of an inflammatory reaction triggered in utero or immediately after birth is associated with the subsequent development of chronic lung disease. However, stimulators of inflammation or specific proinflammatory cytokines may also have beneficial on lung maturation. How proinflammatory mediators interfere with lung maturation and alveolarization needs to be better understood in order to pave the way for new immunomodulatory strategies to prevent chronic lung disease in very preterm infants.
尽管新生儿护理有所改善，但在过去十年中支气管肺发育不良的发病率并未下降。此外，慢性肺病仍会出现在出生时不需要通气支持的极早产儿中。这篇综述展示了越来越多的流行病学、实验和临床证据，表明在子宫内或出生后立即引发的炎症反应与随后慢性肺病的发展有关。然而，炎症刺激物或特定的促炎细胞因子可能对肺成熟也有好处。为了为预防极早产儿慢性肺病的新免疫调节策略铺平道路，需要更好地了解促炎介质如何干扰肺成熟和肺泡化。
