Zupan V, Boithias C, Razafimahefa H, Lamboley G
Service de Réanimation Néonatale, Hôpital Antoine-Béclère, 92141 Clamart Cedex.
J Gynecol Obstet Biol Reprod (Paris). 2001 Feb;30(1 Suppl):85-8.
The outcome of term newborns with birth asphyxia and moderate to severe hypoxic ischemic encephalopathy remains very poor. After the primary phase of energy failure during asphyxia, neuronal cell metabolism may deteriorate in a secondary phase of brain injury. The window between these two phases opens the way to potential neuroprotective treatments such as brain cooling. Promising experimental data on controlled hypothermia need to be examined with clinical trials.
足月新生儿发生窒息以及中重度缺氧缺血性脑病的预后仍然非常差。在窒息期间能量衰竭的初始阶段之后，神经元细胞代谢可能在脑损伤的第二阶段恶化。这两个阶段之间的时间窗为诸如脑部降温等潜在的神经保护治疗开辟了道路。关于控制性低温的有前景的实验数据需要通过临床试验进行检验。
