McGrath J, Chapple B, Wright M
Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol, Australia.
Acta Psychiatr Scand. 2001 Mar;103(3):181-8. doi: 10.1034/j.1600-0447.2001.00114.x.
The aims of this study were to examine working memory in the acute subacute phase of schizophrenia and mania and to examine correlations between working memory and specific symptom domains.
Visuospatial working memory and symptom profiles were assessed in three groups (schizophrenia group, n= 19; mania, n= 12; controls, n= 19) on two occasions separated by 4 weeks.
Both patient groups had significant deficits on working memory compared to the well controls and the schizophrenia and mania groups were equally impaired. All groups showed equivalent improvement over time. In the patient groups, impaired working memory was significantly correlated with the presence of both negative symptoms and positive thought disorder.
Impaired working memory is found in both schizophrenia and mania during the acute subacute phases. Further research is required in order to clarify the neurocognitive mechanisms linking impaired working memory with both negative symptoms and positive thought disorder.
本研究旨在检查精神分裂症和躁狂症急性亚急性期的工作记忆，并检查工作记忆与特定症状领域之间的相关性。
对三组（精神分裂症组，n = 19；躁狂症组，n = 12；对照组，n = 19）进行了两次视觉空间工作记忆和症状特征评估，两次评估间隔4周。
与健康对照组相比，两个患者组在工作记忆方面均存在显著缺陷，且精神分裂症组和躁狂症组的受损程度相当。所有组随时间均显示出同等程度的改善。在患者组中，工作记忆受损与阴性症状和阳性思维障碍的存在均显著相关。
在急性亚急性期的精神分裂症和躁狂症中均发现工作记忆受损。需要进一步研究以阐明将受损的工作记忆与阴性症状和阳性思维障碍联系起来的神经认知机制。
