Steele T H, Rieselbach R E
Nephron. 1975;14(1):21-32. doi: 10.1159/000180433.
The development of our knowledge of the intrarenal process involved in the control of urate excretion in normal man is summarized. Although there are many gaps in our current knowledge, and different interpretations may be given to the available data, current evidence seems to favor the existence of extensive tubular reabsorption of urate following its glomerular filtration. Subsequently, tubular secretion of urate and the reabsorption of an unknown amount of the secreted urate probably take place. For reasons discussed, it seems most likely that the regulation and control of urate excretion are accomplished through modulations in tubular secretion, post-secretory reabsorption, or both.
本文总结了我们对正常人体内尿酸排泄控制过程中肾内机制的认识进展。尽管目前我们的认识存在许多空白，且对现有数据可能有不同解读，但现有证据似乎支持尿酸在肾小球滤过后存在广泛的肾小管重吸收。随后，可能会发生尿酸的肾小管分泌以及分泌的尿酸有未知量的重吸收。基于所讨论的原因，尿酸排泄的调节与控制很可能是通过肾小管分泌或分泌后重吸收的调节，或两者共同作用来实现的。
