Mountokalakis T, Rallis D, Mayopoulou-Symvoulidou D, Komninos Z
Klin Wochenschr. 1979 Dec 3;57(23):1299-1301. doi: 10.1007/BF01492986.
Furosemide (20 mg) was administered intravenously to 7 healthy volunteers, before and after 4 days of oral administration of aspirin in uricosuric dosage (1 g daily). Aspirin prevented the decrease in urinary urate excretion induced by furosemide, without interfering with its natriuretic action. This finding is suggested to be the result of the opposite and independent effects of the two drugs on tubular reabsorption of urate.
在7名健康志愿者口服促尿酸尿剂量的阿司匹林（每日1克）4天前后，静脉注射速尿（20毫克）。阿司匹林可防止速尿引起的尿尿酸排泄减少，且不干扰其利钠作用。这一发现被认为是两种药物对尿酸肾小管重吸收产生相反且独立作用的结果。
