Schuff N, Rooney W D, Miller R, Gelinas D F, Amend D L, Maudsley A A, Weiner M W
DVA Medical Center and Department of Radiology, University of California-San Francisco, San Francisco, California 94121, USA.
Magn Reson Med. 2001 Mar;45(3):513-6. doi: 10.1002/1522-2594(200103)45:3<513::aid-mrm1067>3.0.co;2-d.
The goal of this work was to reexamine previously published (1) brain spectroscopy data of abnormal metabolite ratios in amyotrophic lateral sclerosis (ALS). Toward this goal, (1)H MR spectroscopic imaging data from 10 ALS and nine control subjects were reanalyzed using improved data analysis techniques, including automated curve fitting and tissue-volume correction. In the motor cortex of ALS, N-acetyl aspartate (NAA) was 23% (P = 0.004) lower than in controls, and in the posterior internal capsule of ALS choline compounds (Cho) were 20% (P = 0.02) higher. This demonstrates that the metabolite ratio changes in ALS were due to NAA loss in the motor cortex (as expected) and Cho increase in the posterior internal capsule (not expected). Magn Reson Med 45:513-516, 2001.
这项工作的目标是重新审视先前发表的关于肌萎缩侧索硬化症（ALS）中异常代谢物比率的脑光谱数据。为实现这一目标，使用改进的数据分析技术，包括自动曲线拟合和组织体积校正，对来自10名ALS患者和9名对照受试者的氢质子磁共振波谱成像数据进行了重新分析。在ALS患者的运动皮层中，N-乙酰天门冬氨酸（NAA）比对照组低23%（P = 0.004），而在ALS患者的后内侧囊，胆碱化合物（Cho）比对照组高20%（P = 0.02）。这表明ALS中的代谢物比率变化是由于运动皮层中NAA的减少（如预期）和后内侧囊中Cho的增加（未预期）。《磁共振医学》45:513 - 516, 2001年。
