Laforga J B, Jover A, Martínez P
Department of Pathology, Hospital Marina Alta, Denia, Spain.
Diagn Cytopathol. 2001 Mar;24(3):209-14. doi: 10.1002/1097-0339(200103)24:3<209::aid-dc1043>3.0.co;2-5.
We describe the cytological features of a soft-tissue high-grade spindle and pleomorphic sarcoma. The smears showed hypercellularity composed of pleomorphic round and elongated cells, and a striking population of multinucleated osteoclast-type giant cells. Microscopically the tumor showed multiple patterns such as highly cellular pleomorphic, less cellular, and hyalinized areas with neoplastic cartilage and osteoid, and areas with hemorrhage and multicystic appearance with numerous osteoclastic giant cells, resembling aneurysmal bone cysts. Immunohistochemical studies showed positivity for vimentin, while chondroid tissue was positive for S-100, and osteoclastic giant cells stained positively for CD68. Due to the varied microscopic patterns, the differential diagnosis included many tumors containing osteoclastic giant cells and osteochondroid tissue.
我们描述了一种软组织高级别梭形和多形性肉瘤的细胞学特征。涂片显示细胞增多，由多形性圆形和细长形细胞组成，并有大量多核破骨细胞样巨细胞。显微镜下，肿瘤呈现多种模式，如高度细胞性多形性、细胞较少的区域、伴有肿瘤性软骨和类骨质的玻璃样变区域，以及伴有出血和多囊外观且有大量破骨细胞样巨细胞的区域，类似动脉瘤样骨囊肿。免疫组织化学研究显示波形蛋白呈阳性，软骨样组织S-100呈阳性，破骨细胞样巨细胞CD68染色呈阳性。由于显微镜下模式多样，鉴别诊断包括许多含有破骨细胞样巨细胞和骨软骨样组织的肿瘤。
